VARIABLE DOSE RESPONSE RELATIONS OF VCR ON HUMAN LYMPHOCYTES IN VITRO
RACHEL THOMAS JACOB *
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, India
O. S. REDDI *
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, India
P. P. REDDY *
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, India
*Author to whom correspondence should be addressed.
Abstract
The dose response, and time dependent relationships for chromosome aberrations has been studied in peripheral blood lymphocytes after introduction of the antineoplastic drug, vincristine sulfate in vitro. The percentage of abnormalities were found to be greater at higher concentrations as compared to control.
Keywords: Vincristine sulfate, Chromosome aberrations, Dose response, Time dependent