OBSERVATIONS ON THE USE OF PROTEASE EX ASPERGILLUS ORYZAE IN THE STUDY OF THE INFLAMMATORY PROCESS IN MICE
VACLAV SUTIAK *
Department of Pharmacology,Komensky St. 73,041 81 Kosice, Slovakia, Central Europe.
IRENA SUTIAKOVA *
Department of PharmacologyKomensky St. 73,041 81 Kosice, Slovakia, Central Europe.
JOJEF NEUCHL *
Department of Pharmacology,Komensky St. 73,041 81 Kosice, Slovakia, Central Europe.
MARIAN KORENEK *
Department of Biochemistry, Chemistry and Biophysics UVM, Komensky St. 73,041 81 Kosice, Slovakia, Central Europe.
JANA STANICOVA *
Department of Biochemistry, Chemistry and Biophysics UVM, Komensky St. 73,041 81 Kosice, Slovakia, Central Europe.
*Author to whom correspondence should be addressed.
Abstract
Anti-inflammatory drugs are still required for therapeutic purposes. Their testing and verification must be realized without unnecessary animal pain and stress. That is why various pain alleviating analgesics or local/general anaesthetics and their combinations must be used. Here we present our observations on the inflammatory process induced by protease ex Aspergillus Oryzae (hereafter PAO, only).
Keywords: Mouse, inflammation, protease ex Aspergillus Oryzae